blatant-why

Overview

Blatant-Why is an AI-powered biologics design campaign agent that orchestrates multiple specialized tools through 11 MCP servers. It integrates BoltzGen, PXDesign, Protenix and 200+ cloud tools for antibody, nanobody, and de novo binder design. The platform enables end-to-end design campaigns from target research to lab-ready candidate ranking, with support for both cloud compute (via Tamarind Bio) and local GPU processing.

Try asking AI

After installing, here are 5 things you can ask your AI assistant:

• pdb

  Protein Data Bank queries

  Try:Find all structures of PD-L1 in the PDBTry:Search for antibody structures with specific characteristics
• uniprot

  UniProt protein annotation

  Try:Get detailed annotation for PD-L1 proteinTry:Find post-translational modifications for my target protein
• sabdab

  Structural Antibody Database queries

  Try:Find all known antibodies against PD-L1Try:Search for structural data of therapeutic antibodies
• tamarind

  Tamarind Bio cloud compute

  Try:Run BoltzGen to generate nanobodiesTry:Use Protenix to predict protein structure
• screening

  Screening battery orchestration

  Try:Score generated designs for structural qualityTry:Screen candidates for developability liabilities
• cloud

  Cloud compute abstraction

  Try:Submit job to cloud compute providerTry:Check status of cloud compute jobs
• campaign

  Campaign state management

  Try:Save current campaign stateTry:Load a previous campaign from file
• research

  Literature and target research

  Try:Research PD-L1 literature and known bindersTry:Perform epitope analysis for my target protein
• local_compute

  Local GPU compute dispatch

  Try:Run local protein structure predictionTry:Use local GPU for antibody design
• knowledge

  JSON-backed campaign knowledge store

  Try:Search past campaigns for successful designsTry:Find similar targets and design strategies

Note: Tool names were extracted from the MCP Servers table in the README. Descriptions are taken directly from the table, but no detailed signatures or specific usage examples were provided.

Comparable tools

Installation

# Install uv (Python package manager)
curl -LsSf https://astral.sh/uv/install.sh | sh

# Install Claude Code
npm install -g @anthropic-ai/claude-code

# Initialize your project
mkdir my-campaign && cd my-campaign
npx blatant-why init

# Add API keys
cp .env.example .env
# Edit .env to add your Tamarind API key

# Start designing
claude

FAQ

What compute options are available?

Blatant-Why supports Tamarind Bio (free tier available), local GPU compute, and SSH remote compute. Tamarind Bio provides access to 200+ structural biology tools without requiring local hardware.

How does it integrate with Claude Code?

The platform is designed specifically for Claude Code, providing 11 MCP servers, 16 agents, and 14 skills that extend Claude's capabilities for protein design through the CLAUDE.md orchestration file.

On Hacker News

Recent discussion from the developer community.

• Blatant-Why: Stop paying for AI agent wrappers, start asking what's underneath▲ 3💬 2
  Story by Murfalo · 2026-03-25

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