filesystem vs opentargets-mcp

Side-by-side comparison to help you pick between these two MCP servers.

	filesystem by modelcontextprotocol	opentargets-mcp by nickzren
Stars	★ 85,748	★ 17
30d uses	—	—
Score	77	45
Official	✓	—
Categories	File SystemDeveloper ToolsProductivity	Knowledge GraphAI / LLM ToolsDeveloper Tools
Language	TypeScript	Python
Last commit	this month	this month

filesystem · Summary

A feature-rich MCP server for filesystem operations with dynamic directory access control.

opentargets-mcp · Summary

MCP server providing access to Open Targets biomedical data through 68 curated tools and 3 advanced GraphQL tools.

filesystem · Use cases

Enable AI models to read and write project files during development
Allow Claude or other MCP clients to browse and analyze codebases
Provide secure sandboxed access to specific directories for content generation

opentargets-mcp · Use cases

Prioritizing drug targets by analyzing target-disease associations across 22+ data sources
Repurposing existing drugs for new diseases by exploring multi-hop disease-target-drug evidence chains
Validating genetic variants by accessing GWAS studies with L2G predictions and fine-mapped loci

filesystem · Install

Installation

Using NPX

{
  "mcpServers": {
    "filesystem": {
      "command": "npx",
      "args": [
        "-y",
        "@modelcontextprotocol/server-filesystem",
        "/path/to/allowed/directory"
      ]
    }
  }
}

Using Docker

{
  "mcpServers": {
    "filesystem": {
      "command": "docker",
      "args": [
        "run",
        "-i",
        "--rm",
        "--mount", "type=bind,src=/path/to/allowed/dir,dst=/projects/allowed/dir",
        "mcp/filesystem",
        "/projects"
      ]
    }
  }
}

VS Code Extension

Click the installation buttons in the README to install directly in VS Code.

opentargets-mcp · Install

Installation

Using mcpm (Recommended for Claude Desktop)

pip install mcpm
mcpm install opentargets

Using uvx (No installation required)

uvx --from git+https://github.com/nickzren/opentargets-mcp opentargets-mcp

Local Development

git clone https://github.com/nickzren/opentargets-mcp
cd opentargets-mcp
pip install uv
uv sync
uv run python -m opentargets_mcp.server

Claude Desktop Configuration

Add to Claude Desktop config:

{
  "mcpServers": {
    "opentargets": {
      "command": "uv",
      "args": ["run", "python", "-m", "opentargets_mcp.server", "--transport", "stdio"]
    }
  }
}

Comparison generated from public README + GitHub signals. Last updated automatically.