everything vs opentargets-mcp

Side-by-side comparison to help you pick between these two MCP servers.

	everything by modelcontextprotocol	opentargets-mcp by nickzren
Stars	★ 85,748	★ 17
30d uses	—	—
Score	77	45
Official	✓	—
Categories	Developer ToolsAI / LLM ToolsOther	Knowledge GraphAI / LLM ToolsDeveloper Tools
Language	TypeScript	Python
Last commit	this month	this month

everything · Summary

Official MCP test server exercising all protocol features for client builders.

opentargets-mcp · Summary

MCP server providing access to Open Targets biomedical data through 68 curated tools and 3 advanced GraphQL tools.

everything · Use cases

Testing MCP client implementations against all protocol features
Learning MCP protocol capabilities through a reference server
Validating client compatibility with different transport methods

opentargets-mcp · Use cases

Prioritizing drug targets by analyzing target-disease associations across 22+ data sources
Repurposing existing drugs for new diseases by exploring multi-hop disease-target-drug evidence chains
Validating genetic variants by accessing GWAS studies with L2G predictions and fine-mapped loci

everything · Install

NPX (recommended)

{
  "mcpServers": {
    "everything": {
      "command": "npx",
      "args": ["-y", "@modelcontextprotocol/server-everything"]
    }
  }
}

On Windows, use cmd /c:

{
  "mcpServers": {
    "everything": {
      "command": "cmd",
      "args": ["/c", "npx", "-y", "@modelcontextprotocol/server-everything"]
    }
  }
}

Docker

{
  "mcpServers": {
    "everything": {
      "command": "docker",
      "args": ["run", "-i", "--rm", "mcp/everything"]
    }
  }
}

Global install

npm install -g @modelcontextprotocol/server-everything@latest
npx @modelcontextprotocol/server-everything

opentargets-mcp · Install

Installation

Using mcpm (Recommended for Claude Desktop)

pip install mcpm
mcpm install opentargets

Using uvx (No installation required)

uvx --from git+https://github.com/nickzren/opentargets-mcp opentargets-mcp

Local Development

git clone https://github.com/nickzren/opentargets-mcp
cd opentargets-mcp
pip install uv
uv sync
uv run python -m opentargets_mcp.server

Claude Desktop Configuration

Add to Claude Desktop config:

{
  "mcpServers": {
    "opentargets": {
      "command": "uv",
      "args": ["run", "python", "-m", "opentargets_mcp.server", "--transport", "stdio"]
    }
  }
}

Comparison generated from public README + GitHub signals. Last updated automatically.